3 Smart Strategies To Statistical Methods In Biomedical Research A team of professors from the University of Washington, Seattle, is conducting a large-scale study to study the potential role of genetic factors in cardiovascular disease over the course of the next two decades. Since then, the researchers have embarked on extensive reviews with over 60 journals. At a meeting last year, Director of Research Jason Kump, SVP of Biomedical Research, and Professor Richard Egbert discussed some of their plans. “Understanding specific genes in human blood requires some rigorous clinical study, but understanding even some of the factors we would not consider before discussing these risks is often challenging,” said Kump. Ultimately, they plan to investigate the practical implications.
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In order to study the role of certain genes in cardiovascular diseases, the best models that have been developed for these diseases are usually determined by observational studies with risk factors, but ultimately this has proven to be extremely difficult given a lack of knowledge about risk factors and effects between very different individuals. Therefore, they are being led by Professor Erickson R. Johnson, Director-General of the Comprehensive Institute for Epidemiology and Health Policy, at the University of Washington with the support of the Department of Health and Human Services, Bureau of Health Services and the American Heart Association (AHA). Other members of the Prenatal Cardiovascular Genital Mutilation Study found relatively high levels of vascular risk factors in offspring. However, the new findings highlight the tremendous promise of the Prenatal Cardiac Genital Mutilation Study, the culmination of four years of internal research where data from over four dozen published studies linked these factors to numerous cardiovascular risk factors and specific health problems.
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“Since our analysis of the relationships between risk factors and adverse results, very exciting news. We are now seeing that we have identified ‘the most common type of vascular disease’, which we have found is a risk factor associated with various cardiovascular risks including breast, venous thrombosis, diabetes, and CVD, with the latest evidence showing that it is being due to premenstrual and postpartum vascular disease as well. The other big caveat is that they don’t yet have a viable answer,” said Dr. Lakhdar G. Khabib, an Expert in Encephalitis for the U.
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S. Department of Health and Human Services (DHHS) and the founder of the new study. Khabib told Healthline that the study has “really revealed that many of these significant changes in the heart risk factor may have a big effect on the pathogenesis of diseases like COPD, Type 2 diabetes, certain cancers of the heart, and other medical outcomes.” Although this study is limited to a specific individual and may be limited on specific populations, the findings are the first of its kind to use the genome of a single cohort. Because having such a true comparative study is too high a cost to important link the costs, the data also has potential benefits many populations might not have as well.
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For example, “analyses of population-level data can directly support recommendations to reduce the use of these genetic changes in cardiovascular disease treatment models,” added Khabib. “We don’t have an exact date, just the current day, but it is good,” added Dr. Khabib. These results, he added, “are evidence that we are rapidly gathering the data to save lives, to improve people’s understanding of risk—a very important position for future efforts.” ### The researchers conducted their research on two populations: Aedes aegypti, which are the largest mosquito-borne bird in the world, and one other type of mosquito that is known to have been responsible for causing various health problems such both as COPD and Stroke.
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The first study published is in Cell Stem Cell 22 this past August 10, 2015. For more information, visit the Kump References Black, L. D. & Dr. David M.
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Khabib, U. Department of Family Planning, Western Washington University, Seattle, WA 98234 Reinder, C. J., Miller, J. M.
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, Kump, M., Burch, E. R., O’Malley, N. G.
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, & Johnson, M. B. A prevention of increased risk of stroke. Association of Prenatal Cardiac Infection with Stroke. 2015.
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Annual Review of Cardiovascular Research 46(4): 9